Human Atrial Action Potential and Ca2+Model
نویسندگان
چکیده
منابع مشابه
Action potential duration restitution kinetics in human atrial fibrillation.
OBJECTIVES We undertook this study to determine whether human atrial fibrillation (AF) relates to steeply sloped action potential duration restitution (APDR) kinetics and whether the spatial nonuniformity of APDR promotes persistence of AF. BACKGROUND A steeply sloped APDR curve is known to be an important determinant of the induction of more complex action potential duration (APD) dynamics a...
متن کاملThe two components of the human atrial action potential.
Action potentials studied in 36 human atrial strips at 27 °C were found to be separated into two components. Simultaneous recordings with two microelectrodes demonstrated an independent conduction of the second component through selective and variable pathways. Increased separation of the two components was elicited by higher rate and lower intensity of stimulation, high K, low Ca, hypertonic s...
متن کاملIntegrative Physiology Human Atrial Action Potential and Ca Model Sinus Rhythm and Chronic Atrial Fibrillation
Methods and Results: Atria versus ventricles have lower IK1, resulting in more depolarized resting membrane potential ( 7 mV). We used higher Ito,fast density in atrium, removed Ito,slow, and included an atrial-specific IKur. INCX and INaK densities were reduced in atrial versus ventricular myocytes according to experimental results. SERCA function was altered to reproduce human atrial myocyte ...
متن کاملInter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation
AIMS Human atrial electrophysiology exhibits high inter-subject variability in both sinus rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely investigated in experimental and theoretical electrophysiological studies, thus hampering the understanding of its underlying causes but also its implications in explaining differences in the response to disease and t...
متن کاملAlternans in human atrial monophasic action potenial.
This report describes the case of a patient with a supraventricular tachycardia with a ventricular rate of 109/min and no visible P waves in the electrocardiogram. The recording of the monophasic action potential of the right atrium disclosed an atrial tachycardia with a rate of 218/min. There was an alternans of the phase 2 of repolarisation in the action potential. This report emphasises the ...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2011
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.111.253955